The phenotype of some spontaneous mutations in Drosophila can be modified by mutations at unlinked loci. The affected alleles are caused by the insertion of retroviral transposable elements. The idiosyncratic functional and structural properties of these elements play a key role in determining the expression characteristics of the genes into which they are inserted. These phenotypes are reversed or intensified by the allelic state of suppressor and enhancer loci through changes in the transcriptional properties of the transposable elements.

In this essay, through the concepts of cosmotechnics and technodiversity proposed by Yuk Hui, I present an exploratory sketch regarding the search for a Mesoamerican cosmotechnics from the perspective of the deep relationship that pre-Hispanic cultures have maintained with maize since ancient times. I consider that this relationship expresses a particular Mesoamerican cosmotechnics that—in Hui’s terms—manages to unify “the cosmic order and the moral order through technical activities” in these societies, even to the present day. Similarly, I argue that the (...) biological, agricultural, and gastronomic techniques—such as the milpa, chinampas, and nixtamalization—which have historically been woven around maize are an example of technodiversity that has persisted and withstood the onslaught of the capitalist logic. Finally, I affirm that this cosmotechnics has the potential to be configured as a cosmopolitics that must first overcome the obstacles of nationalist and identity discourses that became prevalent in post-revolutionary Mexico through the indigenist turn, and that are currently configured around the defence of traditional maize against the attempts to introduce its transgenic equivalent in recent decades. (shrink)

The main thesis of this dissertation is set out in its very title, and to prove it will be necessary to eliminate the usual negative or melodramatic meaning of the two concepts that appear there and take them rather as the two extremes of the dialectical process of redefining the sociopersonal consciousness. In accordance with this, any catastrophe implies the violent breakup of the normal conditions of existence due to a natural or human factor whose direct consequences each one must (...) understand and overcome on the triple ontological, social, and psychological determinations of the self. For its part, tragedy stands for the phase of critical and reflective integration that follows the catastrophe, which goes a lot beyond the sheer negativity of sorrow and even death, since even if the person or the people carried away by the catastrophe die, others will be able to make the most of that and the sociopersonal consciousness will be rearticulated. Of course, this implies that the self at issue is not only the individual one, so that other members of the lifeworld must be considered for the phenomenon to reveal a new or critical sense of existence beyond any previous approach to it. Thus, although there is an undeniably negativity throughout, it aims at a deeper level of comprehension of existence, which finally implicates that catastrophe is contextualized in a concrete cultural framework and not only as a sudden unsettlement and that tragedy is accordingly conceived as a philosophical tool more than as a literary genre that deals with the cruelty of fate. To get its aims, the dissertation will be divided into three sections of variable length: in the first one it will be analysed the experience and sense of catastrophe; in the second one, that of tragedy; in the third one, it will briefly be shown why understanding the nexus of both phenomena is axial for the current intellectual dynamics. (shrink)

BackgroundPreprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is completeness of reporting, as transparency can improve the reader’s ability to independently interpret data and reproduce findings.MethodsIn this observational study, we initially compared independent samples of articles published in bioRxiv and in PubMed-indexed journals in 2016 using a quality of reporting questionnaire. After that, we performed paired comparisons (...) between preprints from bioRxiv to their own peer-reviewed versions in journals.ResultsPeer-reviewed articles had, on average, higher quality of reporting than preprints, although the difference was small, with absolute differences of 5.0% [95% CI 1.4, 8.6] and 4.7% [95% CI 2.4, 7.0] of reported items in the independent samples and paired sample comparison, respectively. There were larger differences favoring peer-reviewed articles in subjective ratings of how clearly titles and abstracts presented the main findings and how easy it was to locate relevant reporting information. Changes in reporting from preprints to peer-reviewed versions did not correlate with the impact factor of the publication venue or with the time lag from bioRxiv to journal publication.ConclusionsOur results suggest that, on average, publication in a peer-reviewed journal is associated with improvement in quality of reporting. They also show that quality of reporting in preprints in the life sciences is within a similar range as that of peer-reviewed articles, albeit slightly lower on average, supporting the idea that preprints should be considered valid scientific contributions. (shrink)

We examine access to institutions and opportunity for entrepreneurs in a rising tech economy. A significant proportion of entrepreneurs and CEOs of tech firms in the American economy are either first- or second-generation immigrant minorities. Are these minority entrepreneurs assimilating into a rising economic elite? To what extent is the technology economy segmented by ethnic boundaries and sectors? On a range of empirical measures, including access to financial and social capital, firm performance, and normative beliefs on fairness and cooperation, we (...) find second-generation immigrant minority tech entrepreneurs to be strikingly similar to their white counterparts. This study sheds new light on the institutional environment of a new regional technology economy, whereby barriers of entry are high in terms of human capital but economic competition is structurally and culturally open to immigrant minority entrepreneurs. (shrink)

Diatoms are a species‐rich group of photosynthetic eukaryotes, with enormous ecological significance and great potential for biotechnology. During the last decade, diatoms have begun to be studied intensively using modern molecular techniques and the genomes of four diatoms have been wholly or partially sequenced. Although new insights into the biology and evolution of diatoms are accumulating rapidly due to the availability of reverse genetic tools, the full potential of these molecular biological approaches can only be fully realized if experimental control (...) of sexual crosses becomes firmly established and widely accessible to experimental biologists. Here we discuss the issue of choosing new models for diatom research, by taking into account the broader context of diatom mating systems and the place of sex in relation to the intricate cycle of cell size reduction and restitution that is characteristic of most diatoms. We illustrate the results of our efforts to select and develop experimental systems in diatoms, using species with typical life cycle attributes, which could be used as future model organisms to complement existing ones. BioEssays 30:692–702, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

La sociologie est née parallèlement à la modernisation occidentale ; ses principales positions héritées de l’ère classique portent sur la modernité et son impact sur les sociétés nationales. Après la décolonisation, la modernisation du « Tiers-Monde » a ouvert la voie à la notion de globalisation. La sociologie de la globalisation est une spécialité actuelle au sein des associations américaines et européennes de sociologie. La promesse d’une sociologie globale est à l’ordre du jour de l’Association internationale de sociologie depuis au (...) moins 1990. À un niveau plus profond, la sociologie globale exige de ne pas penser le rôle de concepts fondamentaux tels que la modernité, la religion ou la société par rapport à leurs origines occidentales. Les études globales et la sociologie postcoloniale, deux des domaines de recherche les plus connus qui revendiquent une visée globale, sont examinées afin de déterminer si elles fournissent des ressources conceptuelles adéquates pour la sociologie globale. Si les programmes de recherche de ces deux disciplines offrent des perspectives prometteuses, l’enquête suggère que toutes deux souffrent d’importants inconvénients. La tradition sociologique se trouve aujourd’hui dans une impasse ; la fragmentation peut persister, mais d’autres possibilités existent également. Aucune solution de grande ampleur n’est peut-être possible. Une sociologie véritablement mondiale pourrait finalement émerger des interprétations originales qui se développent à partir de parcours historiques non occidentaux. (shrink)

Analizar epistemológicamente los problemas de salud requiere incorporar la epistemología a los programas de posgrado en ciencias de la salud. Con el propósito de caracterizar los campos problemáticos que fundamenten el diseño de un programa académico para el curso de epistemología en ciencias de la salud se realizó un estudio con el enfoque de la hermenéutica gadameriana en tres etapas. El punto de partida expone la concepción de hombre, conocimiento y epistemología. El horizonte de comprensión se elaboró con tendencias epistemológicas (...) hegemónicas. La fusión de horizontes integró las características de los siguientes campos problemáticos: epistemología de las ciencias de la salud, lógica de las ciencias de la salud, tendencias epistemológicas en ciencias de la salud, problemas epistemológicos de las ciencias de la salud. Se concluye que los campos problemáticos descritos introducen al estudiante a la reflexión de su práctica científica mediante el análisis racional, axiológico y crítico. Analyzing health problems from an epistemological point of view requires epistemology to be included on health sciences postgraduate courses programs. Aimed at characterizing the problematic fields used as basis for the design of a health sciences epistemology academic program, a study with an approach to Gadamer hermeneutics in three stages was carried out. The starting point shows man, knowledge and epistemology conceptions. The comprehension horizon was made with epistemological-dominant trends. The horizons merge included characteristics from the following problematic fields: health sciences epistemology, health sciences logic, epistemological trends in health sciences, health sciences epistemological problems. It was reached the conclusion that the described problematic fields introduce students to their scientific practice reflection through a rational, axiological and critical analysis. (shrink)

ObjectiveTo prospectively study the cingulate cortex for the localization and role of the grasping action in humans during electrical stimulation of depth electrodes.MethodsAll the patients with intractable focal epilepsy and a depth electrode stereotactically placed in the cingulate cortex, as part of their pre-surgical epilepsy evaluation from 2015 to 2017, were included. Cortical stimulation was performed and examined for grasping actions. Post-implantation volumetric T1 MRIs were co-registered to determine the exact electrode position.ResultsFive patients exhibited contralateral grasping actions during electrical stimulation. (...) All patients had electrodes implanted in the ventral bank of the right cingulate sulcus adjacent to the vertical anterior commissure line. Stimulation of other electrodes in adjacent regions did not elicit grasping.ConclusionGrasping action elicited from a localized region in the mid-cingulate cortex directly supports the concept of the cingulate cortex being crucially involved in the grasping network. This opens an opportunity to explore this region with deep brain stimulation as a motor neuromodulation target for treatment in specific movement disorders or neurorehabilitation. (shrink)

In 1960, E. P. Wigner, a joint winner of the 1963 Nobel Prize for Physics, published a paper titled On the Unreasonable Effectiveness of Mathematics in the Natural Sciences [61]. This paper can be construed as an examination and affirmation of Galileo's tenet that “The book of nature is written in the language of mathematics”. To this effect, Wigner presented a large number of examples that demonstrate the effectiveness of mathematics in accurately describing physical phenomena. Wigner viewed these examples as (...) illustrations of what he called the empirical law of epistemology, which asserts that the mathematical formulation of the laws of nature is both appropriate and accurate, and that mathematics is actually the correct language for formulating the laws of nature. At the same time, Wigner pointed out that the reasons for the success of mathematics in the natural sciences are not completely understood; in fact, he went as far as asserting that “… the enormous usefulness of mathematics in the natural sciences is something bordering on the mysterious and there is no rational explanation for it.”. (shrink)

In some recent papers (G. ‘t Hooft and others), it has been argued that quantum mechanics can arise from classical cellular automata. Nonetheless, G. Shpenkov has proved that the classical wave equation makes it possible to derive a periodic table of elements, which is very close to Mendeleyev’s one, and describe also other phenomena related to the structure of molecules. Hence the classical wave equation complements Schrödinger’s equation, which implies the appearance of a cellular automaton molecular model starting from classical (...) wave equation. The other studies show that the microworld is constituted as a tessellation of primary topological balls. The tessellattice becomes the origin of a submicrospic mechanics in which a quantum system is subdivided to two subsystems: the particle and its inerton cloud, which appears due to the interaction of the moving particle with oncoming cells of the tessellattice. The particle and its inerton cloud periodically change the momentum and hence move like a wave. The new approach allows us to correlate the Klein-Gordon equation with the deformation coat that is formed in the tessellatice around the particle. The submicroscopic approach shows that the source of any type of wave movements including the Klein-Gordon, Schrödinger, and classical wave equations is hidden in the tessellattice and its basic exciations – inertons, carriers of mass and inert properies of matter. We also discuss possible correspondence with Konrad Zuse’s calculating space. (shrink)

The starting point of the investigation is the correspondence between the term and concept of Ego ("I") and the various types of experience. Two main ways of introducing and applying of the term "I" (Ego) in Russian philosophy are investigated from the semantic-analytical point of view. The first takes the Ego as initially existed either as a spiritual substance or a given form uniting experiences. This way of treating is realized in L. Lopatin's and V. Soloviev's philosophical teachings. The second (...) containing some moments of reflexion on the concept treated the Ego as a result of experience. It was developed in M. Karinskij und G. Spet. In context of difference between the Ego and the subject or consciousness the question of the owner of consciousness is considered. (shrink)

This paper explores Quentin Skinner's historiographical thesis, named linguistic contextualism, as a potential challenge to the dichotomy in contemporary philosophy between the ‘analytical’ and ‘continental’ traditions. This divide, rooted in differing approaches to language and methodology, has led to labeling and categorizing philosophers into these two areas. However, Skinner’s work, drawing on the ideas of R.G. Collingwood, Ludwig Wittgenstein, and John L. Austin, presents a nuanced view that defies easy classification. By emphasizing the importance of historical context and the ways (...) language shapes philosophical inquiry, Skinner’s thesis blurs the boundaries between analytical and continental philosophy. We examine Skinner’s arguments and their implications for the ‘parting of ways’ concept, suggesting that linguistic contextualism challenges the validity of this dichotomy. Ultimately, it argues for the inclusion of linguistic contextualism as a significant alternative within contemporary philosophical discourse, particularly in discussions about metaphilosophy and the limitations of rigid categorizations. (shrink)

The claim that certain fundamental constants of nature are fine tuned for life and that this provides strong evidence for supernatural design is perhaps the best scientific argument for the existence of God since Paley’s watch. Even atheist physicists find these so called “anthropic coincidences” difficult to explain and need to invoke the Weak Anthropic Principle and multiple universes to do so. Certainly if there are many universes, fine tuning is simple. Our form of life was fined tuned to our (...) universe by evolution. While multiple universes are expected from modern cosmological theories, theists and some scientists object that invoking the unobservable is not science. Of course, God is unobservable too, so the best theists can claim is a standoff. This is the first in a series of columns based on a book in the works that attempts to show that the apparent fine tuning of fundamental constants can be understood from basic physics without invoking multiple universes. In some cases the explanation is provable. In other cases, it is not provable but plausible. Fine tuning by design is a God of the Gaps argument. The proponent has the burden if proving that no possible natural explanation can be found. Thus a plausible natural explanation is sufficient to defeat the argument. A list of thirty four parameters that seem to be fine tuned has been assembled by Rich Deem on the God and Science website. Several of Deem’s constants, such as the speed of light in a vacuum, c, Newton’s constant of gravity, G, and Planck’s constant, h, are just arbitrary numbers that are determined simply by the unit system you are using. They can be set equal to any number you want, except zero, with no impact on the physics. So no fine tuning can possibly be involved, just as the number p is not fine tuned. I will focus first on the five parameters that have the most significance because, if interpreted correctly, they seem to pretty much rule out almost any conceivable kind of life without fine tuning: · Ratio of electrons to protons · Ratio of electromagnetic force to gravity Expansion rate of the universe · Mass density of the universe · Cosmological constant I will admit that the features a universe would have for slightly different values of these parameters, all other parameters remaining the same, would render unlikely any form of life even remotely like ours, that is, one that is based on a lengthy process, chemical or otherwise, by which complex matter evolved from simpler matter. Let me discuss each in turn, with the last, the most difficult, reserved for a future column.. (shrink)